Corticobasal degeneration (cbd) and the corticobasal syndrome (cbs) session overview session id corticobasal degeneration (cbd) and the corticobasal syndrome (cbs) duration 20 minutes description this session will provide an overview of corticobasal degeneration and the corticobasal syndrome, including pathology, clinical features, an outline of relevant investigations and management author dominic paviour   session introduction learning objectives by the end of this session you will be able to recognise the clinical features of the cbs discuss differential diagnosis define the pathologic basis of the condition illustrate an approach to the management of the condition   introduction this session focuses on the corticobasal syndrome (cbs) and corticobasal degeneration (cbd), which is a specific pathological entity which can cause the syndrome. First it describes the important features of the condition such as incidence, prevalence and age of onset as well as the specific clinical signs and symptoms that make up the syndrome. Then it explains the pathology underlying the clinical syndrome and where the condition fits within the spectrum of other neurological disorders. Finally, it provides a practical approach to management of the condition. The first section begins with an overview of the historical reports of cbd as an entity. Clinical features of the cbs in 1967, rebeiz et al described 3 patients with progressive slow and awkward movements of one limb. A jerky tremor, dystonia, parkinsonism and gait disturbance were also identified. Pathological analysis revealed degeneration in cortical and basal ganglia structures with swollen 'ballooned' cortical neurons. They coined the term cortico-basal-ganglionic degeneration. viagra for sale cheap viagra online buy cheap viagra buy cheap viagra buy viagra online buy viagra online viagra online buy generic viagra buy viagra Over the next two decades, similar cases were identified and corticobasal degeneration or cbd became a recognised but uncommon diagnosis when presented with a chronic progressive akinetic rigid syndrome with an asymmetric onset and the presence of 'higher' cortical dysfunction (apraxia, cortical sensory loss, or alien limb). Clinical features of the cbs ii cbd is a pathological diagnosis and more recently the term "corticobasal syndrome" (cbs) has been applied to describe patients with the clinical phenotype first identified by rebeiz, in the realisation that a number of differing underlying pathologies can cause it, of which cbd is only one. Cbs typically presents in the 6th to 8th decade, affecting men and women equally. It is a sporadic disease and no clear environmental factors are implicated. It is a rare disease, with an estimated incidence of ~1 per 100,000. However this may be an under estimate because most of the reported series are from movement disorder clinics which means that cbd presenting with a p.  

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